Sky Journal of Biochemistry Research Vol. 5(5), pp. 063-068, October, 2016.  Available online

ISSN 2315-8786 ©2016 Sky Journals


Full Length Research Paper

Effect of dimethoate on some selected metabolites in the brain, liver and muscle of Clarias lazera

Iniobong Reuben Inyang, Kenobi Akio and Sylvester Chibueze Izah*


Environmental Toxicology Research Unit, Department of Biological Sciences, Niger Delta University, Wilberforce Island Bayelsa State, Nigeria.  


Accepted 15 September, 2016




Insecticide is used for the control of insects both in agricultural field and household. This study evaluated the effects of dimethoate on some metabolites in the brain, muscle and liver of Clarias lazera. The C. lazera samples were purchased from a private farm in Tombia Town, Bayelsa State, Nigeria. The fishes were subjected to different concentrations of toxicant 0.00, 2.50, 3.00 and 3.50 ppm for 30 days. The fish samples were dissected and the muscle, brain and liver were collected and analyzed using standard analytical procedure for metabolites (triglyceride, cholesterol, protein and cortisol) in tissues/organs. The result showed significant variations (P<0.05) in most of the metabolites of C. lazera exposed to dimethoate compared to the control. However, the concentration were in the order brain> liver> muscles (cholesterol), Liver> muscles> brain (triglyceride), muscle> liver> brain (Protein), liver> brain> muscles (cortisol). The study showed that dimethoate could alters metabolites of C. lazera thereby hindering proper metabolism of the various organs affected. As such caution should be exercised on the use of dimethoate insecticides so that it will not contaminate surface water that harbors wide range of fish species.


Key words: Aquatic ecosystem, ecotoxicology, fish, insecticides.



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